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Welcome to the pharmacokinetics research group in the

School of Pharmacy at the University of Waterloo.

 

Pharmacokinetics is the quantitative assessment of what the body does to a chemical following exposure. The fate of a chemical in a living organism is a function of its physical-chemical properties as well as the physiology of the organism. Four main concepts form the basis for describing the rate and extent of exposure. These are Absorption, Distribution, Metabolism and Excretion, or ADME for short.

 

Our research is focused on building virtual organisms to study the pharmacokinetics of drugs and environmental contaminants. Physiologically-based pharmacokinetic (PBPK) models provide a mechanistic means of understanding how changes in physiology can affect the ADME of a chemical. PBPK models are predictive and can be used to scale pharmacokinetics among species (e.g., rat to human) and within a species (e.g., healthy adult humans to children or patients) with an eye towards determining the right dose (in medicine) or determining differential risks associated with contaminant exposure (in human health risk assessment).

 

This website will provide you with further details of our current and future pharmacokinetic research. Peruse the list of publications and courses that I teach and email me if you have questions about the research or the website.

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Students interested in graduate studies at either the M.Sc. or Ph.D. level with interests or experience in the following areas:

 

 

can email me directly:  aedginto@uwaterloo.ca