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Selected Publications

Tarek Mohamed, Jacky C K Yeung, Maryam S Vasefi, Michael A Beazely, Praveen P. N. Rao Development and evaluation of multifunctional agents for potential treatment of Alzheimer's Disease: Application to a pyrimidine-2,4-diamine template. Bioorg. Med. Chem. Lett. 2012 (In Press)

Keriman Özadali, Fügen Özkanli, Sarthak Jain, Praveen P. N. Rao, Carlos A. Velázquez-Martínez Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents. Bioorg. Med.Chem. 20, 2912-2922 (2012).

Tarek Mohamed., Praveen P. N. Rao, Alzheimer's disease: Emerging trends in small molecule therapies. Curr. Med. Chem. 18, 4299-4320 (2011).

Rahim, M. R., Praveen P. N. Rao., Bhardwaj, A., Kaur, J., Huang, Z., Knaus, E. E. Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors. Bioorg. Med. Chem. Lett. 21, 6074-6080 (2011).

Tarek Mohamed.; Jacky C. K. Yeung.; Praveen P. N. Rao. Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and  abeta-aggregation inhibitors: synthesis and biological evaluation. Bioorg. Med.Chem. Lett. 21, 5881-5887 (2011).

Praveen P. N. Rao, Tarek Mohamed. Current and emerging at-site pain medications: A review. J. Pain Res. 4, 279-286 (2011).

Tarek Mohamed.; Xiaobei Zhao.; Lila K. Habib.; Jerry Yang.; Praveen P. N. Rao. Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and abeta-aggregation inhibitors. Bioorg. Med.Chem. 19, 2269-2281 (2011).

Tarek Mohamed.; Praveen, P. N. Rao. Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg. Med. Chem. Lett. 20, 3606-3609 (2010).

Praveen, P. N. Rao.; Saad, N. Kabir.; Tarek Mohamed. Nonsteroidal anti-inflammatory drugs (NSAIDs): Progress in small molecule drug development. Pharmaceuticals (2010), 3, 1530-1549.

Yu, G ; Rao, P. N. P.;Chowdhury, M. A.;Addellatif, K. R.;Dong, Y.;Das, D.;Velazquez, C. A.; Suresh, M. R.;Knaus, E. E. Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase. Bioorg. Med. Chem. Lett. 20, 2168-2173 (2010).

Gang Yu, Morshed A. Chowdhury, Khaled R. Abdellatif, Ying Dong, P. N. Praveen Rao, Dipankar Das, Carlos A. Velázquez, Mavanur R. Suresh, Edward E. Knaus. Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Bioorg. Med. Chem. Lett. 20, 896-902 (2010).

P. N. Praveen Rao, Rajesh K. Grover. Apricoxib, a COX-2 inhibitor for the potential treatent of pain and cancer. IDrugs 12, 711-722 (2009).

P. N. Praveen Rao, Edward E. Knaus. Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): COX inhibition and beyond. J. Pharm. Pharm. Sci. 11, 81s-110s (2008).

Zarghi A, P. N. Praveen Rao, Edward E. Knaus. Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 (COX-2) inhibitors: Replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere. J. Pharm. Pharm. Sci. 10, 159-167 (2007).  

Qiao-Hong Chen, P. N. Praveen Rao, Edward E. Knaus. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs). Bioorg. Med. Chem. 14, 7898-7909 (2006).

P. N. Praveen Rao, Qiao-Hong Chen, Edward E. Knaus. Synthesis and structure-activity relationship studies of 1,3-diphenylprop-2-yn-1-ones: Dual inhibitors of cyclooxygenases and lipoxygenases. J. Med. Chem. 49, 1668-1683 (2006).

P. N. Praveen Rao, Qiao-Hong Chen, Edward E. Knaus. Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs). Bioorg. Med. Chem. Lett. 15, 4842-4845 (2005).

Carlos Velázquez, P. N. Praveen Rao, Robert McDonald, Edward E. Knaus. Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents. Bioorg. Med. Chem. 13, 2749-2757 (2005). 

Qiao-Hong Chen, P. N. Praveen Rao, Edward E. Knaus. Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: A novel class of cyclooxygenase-2 (COX-2) inhibitors.  Bioorg. Med. Chem. 13, 2459-2468 (2005).

P. N. Praveen Rao, Md. Jashim Uddin, Edward E. Knaus. Design, synthesis and structure-activity relationship (SAR) studies of substituted-3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors J. Med. Chem. 47, 3972-3990 (2004). 

Md. Jashim Uddin, P. N. Praveen Rao, Edward E. Knaus. Methylsulfonyl and hydroxyl substituents induce (Z)-stereocontrol in the McMurry olefination reaction. Synlett 1513-1516 (2004).

P. N. Praveen Rao, Mohsen Amini, Huiying Li, Amgad G. Habeeb, Edward E. Knaus. Design, synthesis and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. J. Med. Chem. 46, 4872-4882 (2003).

P. N. Praveen Rao, Mohsen Amini, Huiying Li, Amgad G. Habeeb, Edward E. Knaus. 6-alkyl, alkoxy or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. Bioorg. Med. Chem. Lett. 13, 2205-2209 (2003).

Md. Jashim Uddin, P. N. Praveen Rao, Edward E. Knaus. Design and synthesis of novel rofecoxib analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the methylsulfonyl pharmacophore by a sulfonylazide bioisostere. J. Heterocyl. Chem. 40, 861-868 (2003). 

 

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